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CasNo： 1213269-26-1
MF： C22H25ClN6O2
The covalent binding nature of irreversi...
Compositions of the invention comprise 1...
A series of thirty two anilinopyrimidine...
The clinical success of covalent kinase ...
5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)pyrimidin-2-amine
4-(3-aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl) pyrimidin-2-amine
| Conditions | Yield |
|---|---|
|
With
ammonium chloride;
iron;
In
tetrahydrofuran; water;
at 65 ℃;
for 4h;
|
76% |
|
With
iron; ammonium chloride;
In
tetrahydrofuran; water;
at 65 ℃;
for 4h;
|
76% |
|
With
iron; ammonium chloride;
In
tetrahydrofuran; water;
at 70 ℃;
for 6h;
|
41% |
|
With
platinum(IV) oxide; hydrogen;
In
methanol;
|
|
|
With
iron; ammonium chloride;
In
tetrahydrofuran; water;
for 3h;
Reflux;
|
|
|
With
ammonium chloride; zinc;
In
tetrahydrofuran; methanol;
at 0 - 20 ℃;
for 18h;
|
1.19 g |
2-methoxy-4-(4-methylpiperazin-1-yl)aniline
4-(3-aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl) pyrimidin-2-amine
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: trifluoroacetic acid / iso-butanol / 100 °C
2: platinum(IV) oxide; hydrogen / methanol
With
platinum(IV) oxide; hydrogen; trifluoroacetic acid;
In
methanol; iso-butanol;
|
|
|
Multi-step reaction with 2 steps
1: trifluoroacetic acid / iso-butanol / 3 h / Reflux
2: iron; ammonium chloride / tetrahydrofuran; water / 3 h / Reflux
With
iron; ammonium chloride; trifluoroacetic acid;
In
tetrahydrofuran; water; iso-butanol;
|
|
|
Multi-step reaction with 2 steps
1: trifluoroacetic acid / butan-1-ol / 18 h / 100 °C
2: zinc; ammonium chloride / methanol; tetrahydrofuran / 18 h / 0 - 20 °C
With
ammonium chloride; trifluoroacetic acid; zinc;
In
tetrahydrofuran; methanol; butan-1-ol;
|
|
|
Multi-step reaction with 2 steps
1: trifluoroacetic acid / iso-butanol / 4 h / 100 °C
2: iron; ammonium chloride / tetrahydrofuran; water / 4 h / 65 °C
With
iron; ammonium chloride; trifluoroacetic acid;
In
tetrahydrofuran; water; iso-butanol;
|
|
|
Multi-step reaction with 2 steps
1: trifluoroacetic acid / iso-butanol / 5 h / Reflux
2: ammonium chloride; iron / water; tetrahydrofuran / 6 h / 70 °C
With
iron; ammonium chloride; trifluoroacetic acid;
In
tetrahydrofuran; water; iso-butanol;
|
5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)pyrimidin-2-amine
2-methoxy-4-(4-methylpiperazin-1-yl)aniline
2,5-dichloro-4-(3-nitrophenoxy)pyrimidine
meta-nitrophenol
N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(dimethylamino)propanamide
N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(diethylamino)propanamide
N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(pyrrolidin-1-yl)propanamide
