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AP26113

Detailed Information

  • Product Name:AP26113
  • CasNo.:1197958-12-5
  • MF:C26H34ClN6O2P
  • MW:529.01

pd_nature

  • Purity:99%
  • pd_boiling:
  • Packing:
  • Throughput:

Product Details;

CasNo： 1197958-12-5

MF： C26H34ClN6O2P

Reputable factory supply AP26113 1197958-12-5 in stock with high standard

  • Molecular Formula:C26H34ClN6O2P
  • Molecular Weight:529.01
  • Boiling Point:737.6±70.0 °C(Predicted) 
  • PKA:9.27±0.20(Predicted) 
  • PSA：95.66000 
  • Density:1.29±0.1 g/cm3(Predicted) 
  • LogP:4.96410 

1197958-12-5 Relevant articles

Preparation method for antitumor drug AP26113

-

Page/Page column 8, (2018/08/24)

Disclosed is a preparation method for an...

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase

Huang, Wei-Sheng,Liu, Shuangying,Zou, Dong,Thomas, Mathew,Wang, Yihan,Zhou, Tianjun,Romero, Jan,Kohlmann, Anna,Li, Feng,Qi, Jiwei,Cai, Lisi,Dwight, Timothy A.,Xu, Yongjin,Xu, Rongsong,Dodd, Rory,Toms, Angela,Parillon, Lois,Lu, Xiaohui,Anjum, Rana,Zhang, Sen,Wang, Frank,Keats, Jeffrey,Wardwell, Scott D.,Ning, Yaoyu,Xu, Qihong,Moran, Lauren E.,Mohemmad, Qurish K.,Jang, Hyun Gyung,Clackson, Tim,Narasimhan, Narayana I.,Rivera, Victor M.,Zhu, Xiaotian,Dalgarno, David,Shakespeare, William C.

, p. 4948 - 4964 (2016/06/13)

In the treatment of echinoderm microtubu...

1197958-12-5 Process route

N<sub>2</sub>-[4-[4-(dimethylamino)-1-piperidyl]-2-methoxyphenyl]-N<sub>4</sub>-[2-(dimethylphosphoryl)phenyl]-2,4-diaminopyrimidine

N2-[4-[4-(dimethylamino)-1-piperidyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphoryl)phenyl]-2,4-diaminopyrimidine

(2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl )amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
1197958-12-5

(2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl )amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Conditions
Conditions Yield
With N-chloro-succinimide; In acetonitrile; at 20 ℃;
66.3%
1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidine-4-amine
1089279-91-3

1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidine-4-amine

(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide
1197953-49-3

(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide

(2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl )amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
1197958-12-5

(2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl )amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Conditions
Conditions Yield
With hydrogenchloride; In ethanol; 2-methoxy-ethanol; at 120 ℃; for 6h;

1197958-12-5 Upstream products

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    (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide

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    1-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidine-4-amine

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