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CasNo: 871700-18-4
MF: C10H10FIN2O
The present invention relates to a pyrim...
1,1'-carbonyldiimidazole
Cyclopropylamine
N-(2-fluoro-4-iodophenyl)-N'-cyclopropylurea
Conditions | Yield |
---|---|
2-fluro-4-iodoaniline; 1,1'-carbonyldiimidazole;
With
toluene-4-sulfonic acid 3-cyclopropyl-8-methyl-1-(3-nitrophenyl)-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl ester;
In
DMF (N,N-dimethyl-formamide);
at 0 - 20 ℃;
for 5 - 18h;
Cyclopropylamine;
In
DMF (N,N-dimethyl-formamide);
at 0 - 20 ℃;
for 1h;
Product distribution / selectivity;
|
93.4% |
N-(2-fluoro-4-iodophenyl)-N'-cyclopropylurea
malonic acid
1-cyclopropyl-3-(2-fluoro-4-iodophenyl)pyrimidine-2,4,6-trione
Conditions | Yield |
---|---|
With
acetic anhydride; acetyl chloride;
at 60 ℃;
for 3h;
|
82% |
1,1'-carbonyldiimidazole
Cyclopropylamine
1-cyclopropyl-3-(2-fluoro-4-iodophenyl)pyrimidine-2,4,6-trione
1-(2-cyanoacetyl)-1-cyclopropyl-3-(2-fluoro-4-iodophenyl)urea
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione