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Brigatinib

Detailed Information

  • Product Name:Brigatinib
  • CasNo.:1197953-54-0
  • MF:C29H39ClN7O2P
  • MW:584.09

pd_nature

  • Purity:99%
  • pd_boiling:
  • Packing:
  • Throughput:

Product Details;

CasNo： 1197953-54-0

MF： C29H39ClN7O2P

Reputable manufacturer supply Brigatinib 1197953-54-0 in stock with high standard

  • Molecular Formula:C29H39ClN7O2P
  • Molecular Weight:584.09
  • Boiling Point:781.8±70.0 °C(Predicted) 
  • PKA:8.14±0.42(Predicted) 
  • PSA：95.67000 
  • Density:1.31±0.1 g/cm3(Predicted) 
  • LogP:5.17680 

1197953-54-0 Relevant articles

Brigatinib intermediate, salt thereof, preparation method thereof and preparation method of brigatinib

-

, (2021/01/29)

The invention relates to the technical f...

Preparation method of ALK inhibitor Brigatinib

-

Paragraph 0059-0063, (2020/06/02)

The invention relates to the technical f...

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase

Huang, Wei-Sheng,Liu, Shuangying,Zou, Dong,Thomas, Mathew,Wang, Yihan,Zhou, Tianjun,Romero, Jan,Kohlmann, Anna,Li, Feng,Qi, Jiwei,Cai, Lisi,Dwight, Timothy A.,Xu, Yongjin,Xu, Rongsong,Dodd, Rory,Toms, Angela,Parillon, Lois,Lu, Xiaohui,Anjum, Rana,Zhang, Sen,Wang, Frank,Keats, Jeffrey,Wardwell, Scott D.,Ning, Yaoyu,Xu, Qihong,Moran, Lauren E.,Mohemmad, Qurish K.,Jang, Hyun Gyung,Clackson, Tim,Narasimhan, Narayana I.,Rivera, Victor M.,Zhu, Xiaotian,Dalgarno, David,Shakespeare, William C.

, p. 4948 - 4964 (2016/06/13)

In the treatment of echinoderm microtubu...

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL] PYRIMIDINE-2,4-DIAMINE

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Paragraph 00373; 00374; 00375, (2016/05/24)

Crystalline forms of brigatinib, pharmac...

1197953-54-0 Process route

2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]-phenylamine

2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]-phenylamine

(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide
1197953-49-3

(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide

5-chloro-N<sup>4</sup>-[2-(dimethylphosphonyl)phenyl]-N<sup>2</sup>-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine
1197953-54-0

5-chloro-N4-[2-(dimethylphosphonyl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine

Conditions
Conditions Yield
With triethylamine; In 1,2-dimethoxyethane; ethanol; at 120 ℃; for 5h; Sealed tube;
80.3%
With hydrogenchloride; In ethanol; 2-methoxy-ethanol; at 120 ℃; for 5.5h; Sealed tube;
66%
With hydrogenchloride; In ethanol; 2-methoxy-ethanol; at 120 ℃; for 6h; Sealed tube;
65%
With hydrogenchloride; In ethanol; 2-methoxy-ethanol; at 120 ℃;
65%
4-fluoro-2-methoxy-1-nitrobenzene
448-19-1

4-fluoro-2-methoxy-1-nitrobenzene

5-chloro-N<sup>4</sup>-[2-(dimethylphosphonyl)phenyl]-N<sup>2</sup>-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine
1197953-54-0

5-chloro-N4-[2-(dimethylphosphonyl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 120 °C
2: hydrogen; palladium on activated charcoal / ethanol / 3 h / 2585.81 Torr
3: hydrogenchloride / ethanol; 2-methoxy-ethanol / 5.5 h / 120 °C / Sealed tube
With hydrogenchloride; palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile / 13 h / 80 °C
2: hydrogen; palladium 10% on activated carbon / ethanol / 2.5 h
3: hydrogenchloride / ethanol; 2-methoxy-ethanol / 6 h / 120 °C / Sealed tube
With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; 2-methoxy-ethanol; acetonitrile;
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile / Reflux
2: palladium 10% on activated carbon; hydrogen / ethanol; water / 10.34 Torr
3: hydrogenchloride / ethanol; 2-methoxy-ethanol / 120 °C
With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; 2-methoxy-ethanol; water; acetonitrile;
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile / 4.5 h / Reflux
2: hydrogen; 15% palladium on carbon / ethanol / 2.5 h / 25 °C / 517.16 Torr
3: triethylamine / ethanol; 1,2-dimethoxyethane / 5 h / 120 °C / Sealed tube
With 15% palladium on carbon; hydrogen; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; acetonitrile;
Multi-step reaction with 5 steps
1.1: potassium carbonate / dimethyl sulfoxide / 5 h / 60 °C
2.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 3.5 h / 20 °C
2.2: 1.5 h / 35 °C
3.1: trifluoroacetic acid / ethanol / 16 h / Inert atmosphere; Reflux
4.1: Jones reagent / acetone / 0.5 h / 20 - 25 °C
5.1: 1,4-dioxane / 0.33 h
5.2: 20 °C
With Jones reagent; palladium on activated charcoal; hydrogen; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; acetone;

1197953-54-0 Upstream products

  • 1197953-49-3
    1197953-49-3

    (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide

  • 615-43-0
    615-43-0

    2-iodophenylamine

  • 1197953-47-1
    1197953-47-1

    (2-aminophenyl)dimethyl phosphorus oxide

  • 448-19-1
    448-19-1

    4-fluoro-2-methoxy-1-nitrobenzene

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