CasNo： 443913-73-3
MF： C22H24BrFN4O2
Appearance： Yellow solid
Quality manufacturer supply Vandetanib 443913-73-3 in stock with high standard We supply high quality Vandetanib (CAS 443913-73-3), in stock, factory directly supply to clients, lower prices, more competitiveness.
Vandetanib is Yellow solid, while it's Molecular Formula is C22H24BrFN4O2. Vandetanib is a broad spectrum, orally available kinase inhibitor that targets primarily tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR), with IC50 values in the nanomolar range. It also potently blocks non-receptor tyrosine kinases, including ABL, RET, and SRC, as well as several serine/threonine kinases. Primarily because of its effects on receptor tyrosine kinases like VEGFR and EGFR, vandetanib inhibits angiogenesis, cell growth, and metastasis and is effective against certain forms of cancer.[Cayman Chemical]
The CAS number of Vandetanib is 443913-73-3.
More information of Vandetanib 443913-73-3 are:
|
Synonyms |
4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;CH 331;ZD 6474;Zactima;N-(4-bromo-2-fluoro-phenyl)-6-methoxy-7-[(1-methyl-4-piperidyl)methoxy]quinazolin-4-amine;4-quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-;N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine; |
|
CAS Number |
443913-73-3 |
|
Molecular Formula |
C22H24BrFN4O2 |
|
Molecular Weight |
475.361 |
|
Density |
1.406 g/cm3 |
|
Melting Point |
240-243 °C |
|
Boiling Point |
538.22 °C at 760 mmHg |
|
Flash Point |
279.306 °C |
|
HS CODE |
29333220 |
|
PSA |
59.51000 |
|
LogP |
5.01510 |
|
Pka |
8.92±0.10(Predicted) |
In April 2011, the U.S. FDA approved vandetanib (ZD6474) for the treatment of symptomatic or progressive medullary thyroid cancer (MTC) in adult patients with inoperable advanced ormetastatic disease. Vandetanib inhibits KDR/VEGFR2, VEGFR3, EGFR, and RET kinases with IC50's of 40, 110, 500, and <100 nM, respectively. In athymic mice bearing MTC tumors, a 14.5-fold reduction of tumor volume was observed after 45 days of treatment with vandetanib at 50 mg/kg/day. The decrease in tumor volume was accompanied by decreases in mitotic index (Ki67) and tumor angiogenesis in treated xenografts. Key steps in the synthesis of vandetanib include the displacement of the chlorine atom from 7-benzyloxy-4-chloro-6-methoxyquinazoline with 4-bromo-2- fluoroaniline under acidic conditions in a protic solvent and a Mitsunobu reaction of a N-protected piperidine alcohol with a phenol.
InChI:InChI=1/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
Articles related to Vandetanib:
|
Article |
Source |
|
Tyrosine kinase inhibitors implant he loni and its key intermediate for the preparation of |
- , (2018/10/19) |
|
Radiosynthesis of [11C]Vandetanib and [11C]chloro- Vandetanib as new potential PET agents for imaging of VEGFR in cancer |
Gao, Mingzhang,Lola, Christian M.,Wang, Min,Miller, Kathy D.,Sledge, George W.,Zheng, Qi-Huang experimental part, p. 3222 - 3226 (2011/07/07) |
SHUNYUANSHENG BIO-PHARMTECH CO., LTD is a quality supplier and manufacturer of Vandetanib . You can buy high quality, low price Vandetanib 443913-73-3 here. Contact us.
