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3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione

Detailed Information

  • Product Name:3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
  • CasNo.:871700-22-0
  • MF:C14H13FIN3O2
  • MW:401.17

pd_nature

  • Purity:99%
  • pd_boiling:
  • Packing:
  • Throughput:

Product Details;

CasNo： 871700-22-0

MF： C14H13FIN3O2

Factory Sells Best Quality 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione 871700-22-0 with ISO standards

  • Molecular Formula:C14H13FIN3O2
  • Molecular Weight:401.17
  • Boiling Point:459.4±55.0 °C(Predicted) 
  • PKA:3.83±0.20(Predicted) 
  • PSA：56.03000 
  • Density:1.85±0.1 g/cm3(Predicted) 
  • LogP:2.19250 

871700-22-0 Relevant articles

Method for synthesizing key intermediate of trametinib

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Paragraph 0029, (2019/02/27)

The invention discloses a method for syn...

5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PYRIDO’2,3-D! PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CANCER

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Page/Page column 146, (2008/06/13)

The present invention relates to a pyrim...

871700-22-0 Process route

N'-[1-cyclopropyl-3-(2-fluoro-4-iodo-phenyl)-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl]-N,N-dimethyl-formamidine
871700-30-0

N'-[1-cyclopropyl-3-(2-fluoro-4-iodo-phenyl)-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl]-N,N-dimethyl-formamidine

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione
871700-22-0

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione

Conditions
Conditions Yield
N'-[1-cyclopropyl-3-(2-fluoro-4-iodo-phenyl)-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl]-N,N-dimethyl-formamidine; With sodium tetrahydroborate; In ethanol; tert-butyl alcohol; at 20 ℃; for 3.5h;
With citric acid; In ethanol; water; tert-butyl alcohol; for 3h; Product distribution / selectivity;
6-chloro-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-1H-pyrimidine-2,4-dione
871700-20-8

6-chloro-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-1H-pyrimidine-2,4-dione

6-chloro-1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-1H-pyrimidine-2,4-dione
871700-21-9

6-chloro-1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-1H-pyrimidine-2,4-dione

methylamine
74-89-5

methylamine

1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione
871700-23-1

1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione
871700-22-0

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione

Conditions
Conditions Yield
In methanol; at 20 ℃; for 2h; Product distribution / selectivity;

871700-22-0 Upstream products

  • 871700-20-8
    871700-20-8

    6-chloro-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-1H-pyrimidine-2,4-dione

  • 871700-21-9
    871700-21-9

    6-chloro-1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-1H-pyrimidine-2,4-dione

  • 74-89-5
    74-89-5

    methylamine

  • 871700-30-0
    871700-30-0

    N'-[1-cyclopropyl-3-(2-fluoro-4-iodo-phenyl)-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl]-N,N-dimethyl-formamidine

871700-22-0 Downstream products

  • 871700-24-2
    871700-24-2

    3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione

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