CasNo： 606143-52-6
MF： C17H15BrClFN4O3
Appearance： White or pale white solid.
The invention relates to a method for pr...
The invention relates to a synthesis met...
The present invention relates to interme...
The present invention relates to Compoun...
![5-[(4-bromo-2-chlorophenyl)amino]-N-[2-(ethenyloxy)ethoxy]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxamide](/upload/2025/5/d97ebcdc-3c00-446a-9e17-bc2ec5157903.png)
5-[(4-bromo-2-chlorophenyl)amino]-N-[2-(ethenyloxy)ethoxy]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxamide
selumetinib
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; water;
In
ethanol;
for 24h;
|
100% |
|
With
hydrogenchloride; water;
In
ethanol;
for 24h;
|
100% |
|
With
hydrogenchloride;
In
ethanol; water;
at 25 - 30 ℃;
for 24h;
|
70% |
![5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid](/upload/2025/5/c4f15403-f9cd-4f93-94a0-e0ce0b3f5b21.png)
5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid
O-(2-hydroxyethyl)hydroxylamine
selumetinib
| Conditions | Yield |
|---|---|
|
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
Temperature;
|
91.5% |
|
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
|
91.5% |
5-[(4-bromo-2-chlorophenyl)amino]-N-[2-(ethenyloxy)ethoxy]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxamide
methyl 5-[(4-bromophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate
methyl 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate
4-Amino-3-fluoro-5-nitro-2-phenylamino-benzoic acid methyl ester
6-(4-bromo-2-chlorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethoxy)amide hydrogen sulphate
C24H26BrClF3N7O3
6-(4-bromo-2-chloroanilino)-7-fluoro-N-[2-(α-D-glucopyranosyloxy)ethoxy]-3-methylbenzimidazole-5-carboxamide
6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide p-toluenesulfonate
