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3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-diMethylpyrido[2,3-d]pyriMidine-2,4,7(1H,3H,8H)-trione

Detailed Information

  • Product Name:3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-diMethylpyrido[2,3-d]pyriMidine-2,4,7(1H,3H,8H)-trione
  • CasNo.:871700-24-2
  • MF:C18H15FIN3O4
  • MW:483.238

pd_nature

  • Purity:99%
  • pd_boiling:
  • Packing:
  • Throughput:

Product Details;

CasNo： 871700-24-2

MF： C18H15FIN3O4

Manufacturer supply high quality 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-diMethylpyrido[2,3-d]pyriMidine-2,4,7(1H,3H,8H)-trione 871700-24-2 with GMP standards

  • Molecular Formula:C18H15FIN3O4
  • Molecular Weight:483.238
  • Boiling Point:518.2±60.0 °C(Predicted) 
  • PKA:4.50±1.00(Predicted) 
  • PSA：86.23000 
  • Density:1.94±0.1 g/cm3(Predicted) 
  • LogP:1.94370 

871700-24-2 Relevant articles

Method for synthesizing key intermediate of trametinib

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Paragraph 0029, (2019/02/27)

The invention discloses a method for syn...

5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PYRIDO’2,3-D! PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CANCER

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Page/Page column 152-153, (2008/06/13)

The present invention relates to a pyrim...

871700-24-2 Process route

N-(2-fluoro-4-iodophenyl)-N'-cyclopropylurea
871700-18-4

N-(2-fluoro-4-iodophenyl)-N'-cyclopropylurea

ethyl 1,5-dimethyl-2,4,6-pyridin-3-carboxylate

ethyl 1,5-dimethyl-2,4,6-pyridin-3-carboxylate

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione
871700-24-2

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione

Conditions
Conditions Yield
With sodium ethanolate; In tetrahydrofuran; at 0 - 60 ℃; for 8h;
14.5 g
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione
871700-22-0

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione

methyl-propanedioic acid
516-05-2

methyl-propanedioic acid

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione
871700-24-2

3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione

Conditions
Conditions Yield
With acetic anhydride;
21%
With acetic anhydride; at 100 ℃; for 3h; Product distribution / selectivity;

871700-24-2 Upstream products

  • 871700-22-0
    871700-22-0

    3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione

  • 516-05-2
    516-05-2

    methyl-propanedioic acid

  • 871700-23-1
    871700-23-1

    1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione

  • 871700-18-4
    871700-18-4

    N-(2-fluoro-4-iodophenyl)-N'-cyclopropylurea

871700-24-2 Downstream products

  • 871700-07-1
    871700-07-1

    trifluoromethanesulfonic acid 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydro-pyrido[2,3-d]pyrimidin-5-yl ester

  • 871700-32-2
    871700-32-2

    3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

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