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2,2,2-trifluoroethanethioamide

Detailed Information

  • Product Name:2,2,2-trifluoroethanethioamide
  • CasNo.:421-52-3
  • MF:C2H2 F3 N S
  • MW:129.106

pd_nature

  • Purity:99%
  • pd_boiling:42-43 °C(Solv: ethyl ether (60-29-7))
  • Packing:
  • Throughput:

Product Details;

CasNo: 421-52-3

MF: C2H2 F3 N S

Reputable factory supply 2,2,2-trifluoroethanethioamide 421-52-3 in stock with high standard

  • Molecular Formula:C2H2 F3 N S
  • Molecular Weight:129.106
  • Vapor Pressure:31.5mmHg at 25°C 
  • Melting Point:42-43 °C(Solv: ethyl ether (60-29-7)) 
  • Refractive Index:1.434 
  • Boiling Point:104°Cat760mmHg 
  • PKA:11.02±0.29(Predicted) 
  • Flash Point:16.7°C 
  • PSA:58.11000 
  • Density:1.49g/cm3 
  • LogP:1.53510 

2,2,2-trifluoroethanethioamide(Cas 421-52-3) Usage

General Description

2,2,2-trifluoroethanethioamide, also known as trifluoroethyl thioacetamide, is a chemical compound with the molecular formula C4H6F3NS. It is a thioamide derivative with three fluorine atoms attached to the carbon atom and a sulfur atom bonded to the nitrogen atom. 2,2,2-trifluoroethanethioamide is used in organic synthesis as a source of nucleophilic 2,2,2-trifluoroethylthio anion, which can participate in a variety of reactions. Additionally, it is also used as a building block for the synthesis of pharmaceuticals and agrochemicals. This chemical has a wide range of industrial applications due to its unique chemical properties and reactivity.

InChI:InChI=1/C2H2F3NS/c3-2(4,5)1(6)7/h(H2,6,7)

421-52-3 Relevant articles

Cycloaddition reactions of polyfluoroalkylthioncarboxylic acid derivatives with dimethyl acetylenedicarboxylate (DMAD)

Rudnichenko,Timoshenko,Shermolovich

, p. 439 - 444 (2004)

Polyfluoroalkyldithiocarboxylates react ...

Compound synthesized from new thiazole monomer including electron withdrawing group and manufacturing method thereof

-

Paragraph 0116-0121, (2019/10/08)

The present invention relates to a compo...

HETEROARYL SUBSTITUTED BETA-HYDROXYETHYLAMINES FOR USE IN TREATING HYPERGLYCAEMIA

-

Page/Page column 47, (2019/04/11)

There is herein provided a compound of f...

SUBSTITUTED OXAZOLE- AND THIAZOLE-BASED CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS II

-

Paragraph 21-22, (2016/06/14)

The invention relates to oxazole and thi...

BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES

-

Page/Page column 109-110, (2009/12/28)

The invention is directed to certain nov...

421-52-3 Process route

2,2,2-trifluoroacetamide
354-38-1

2,2,2-trifluoroacetamide

trifluorothioacetamide
421-52-3

trifluorothioacetamide

Conditions
Conditions Yield
With tetraphosphorus decasulfide; In tetrahydrofuran; at 70 - 75 ℃; for 4h; Inert atmosphere;
95%
With Lawessons reagent; In tetrahydrofuran; for 2h; Heating / reflux;
84%
With Lawessons reagent; In tetrahydrofuran; for 2h; Reflux;
65%
With Lawessons reagent; In tetrahydrofuran; for 6h; Heating;
53%
With tetraphosphorus decasulfide; Hexamethyldisiloxane; In toluene; at 45 ℃; for 15h;
44%
With P2S2; In benzene; for 96h; Heating;
With Lawessons reagent;
With Lawessons reagent; In tetrahydrofuran; for 18h; Heating / reflux;
With Lawessons reagent; In tetrahydrofuran; for 6h; Reflux;
Lawessons reagent
19172-47-5,94367-93-8

Lawessons reagent

2,2,2-trifluoroacetamide
354-38-1

2,2,2-trifluoroacetamide

trifluorothioacetamide
421-52-3

trifluorothioacetamide

Conditions
Conditions Yield
84%

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