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CasNo： 946426-89-7
MF： C13H11Cl2NO2
The farnesoid X receptor (FXR) is a prom...
Herein we report the discovery and precl...
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Acetaminophen (APAP) overdose is a leadi...
ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate
4-(hydroxymethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole
| Conditions | Yield |
|---|---|
|
ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 5.5h;
With
water; rochelle salt;
In
tetrahydrofuran; toluene;
|
96% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at -70 - 20 ℃;
for 16h;
|
89% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
|
78% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
Inert atmosphere;
|
78% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 25 ℃;
|
75% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 7h;
|
60% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 7h;
|
60% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
|
36% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
|
36% |
|
ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
With
hydrogenchloride; water;
In
tetrahydrofuran; methanol;
|
|
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
|
5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-carboxylic acid methyl ester
4-(hydroxymethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole
| Conditions | Yield |
|---|---|
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
|
96% |
|
5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-carboxylic acid methyl ester;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
for 2h;
With
hydrogenchloride; sodium hydroxide; water;
In
tetrahydrofuran; toluene;
|
93% |
|
5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-carboxylic acid methyl ester;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 ℃;
for 2h;
With
hydrogenchloride; water;
In
tetrahydrofuran; toluene;
Product distribution / selectivity;
|
93% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
|
92% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
|
92% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
|
92% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
|
92% |
|
5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-carboxylic acid methyl ester;
With
diisobutylaluminium hydride;
In
dichloromethane; toluene;
at -5 - 25 ℃;
for 3.5h;
With
hydrogenchloride; water;
In
dichloromethane; toluene;
at 8 - 10 ℃;
for 0.5h;
Product distribution / selectivity;
|
90% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -10 - 20 ℃;
for 0.5h;
|
90% |
|
5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-carboxylic acid methyl ester;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
With
methanol;
In
tetrahydrofuran; toluene;
at 0 ℃;
for 0.166667h;
Product distribution / selectivity;
|
85% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
|
85% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
|
84.2% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
|
83% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -10 ℃;
Inert atmosphere;
|
60% |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
|
8.46 g |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 2h;
|
8.46 g |
|
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 6h;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -10 ℃;
for 3h;
|
ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate
5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-carboxylic acid methyl ester
2,6-Dichloro-N-hydroxybenzenecarboximidoyl chloride
2,6-dichlorobenzaldehyde
methyl 7-[4-({[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-isoquinolinecarboxylate
methyl 6-[4-({[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-quinolinecarboxylate
4-(bromomethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole
5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((5-nitro-6-(trifluoromethyl)pyridin-2-yloxy)methyl) isoxazole
