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CasNo： 1186608-79-6
A one-pot multigram synthesis of 3-(trif...
Novel guanylate cyclase stimulators are ...
Compounds of Formula I are useful for in...
Compounds of Formula I are useful for in...
2-fluoropyridine
ethyl trifluoroacetate,
2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethanone
| Conditions | Yield |
|---|---|
|
2-fluoropyridine;
With
lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane;
at -78 ℃;
for 3h;
Cooling with acetone-dry ice;
ethyl trifluoroacetate,;
In
tetrahydrofuran; n-heptane;
at -78 - 20 ℃;
Cooling with acetone-dry ice;
With
hydrogenchloride;
In
tetrahydrofuran; n-heptane; water;
at 20 ℃;
|
90% |
|
2-fluoropyridine;
With
lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane;
at -78 ℃;
Cooling with acetone-dry ice;
ethyl trifluoroacetate,;
In
tetrahydrofuran; n-heptane;
at -78 - 20 ℃;
|
90% |
|
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -75 ℃;
for 4h;
|
|
|
2-fluoropyridine;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -75 ℃;
for 4h;
ethyl trifluoroacetate,;
at -75 - -40 ℃;
|
2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethanone
![3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine](/upload/2025/5/bbb4d241-4ff9-4c83-ba4f-9b53b59c8209.png)
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
| Conditions | Yield |
|---|---|
|
With
hydrazine hydrate;
In
ethanol;
Reflux;
|
85% |
|
With
hydrazine hydrate;
In
ethanol;
Heating;
Reflux;
|
85% |
|
With
hydrazine hydrate;
at -75 - 70 ℃;
|
55% |
|
With
hydrazine hydrate;
at 70 ℃;
for 6h;
|
2-fluoropyridine
ethyl trifluoroacetate,
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine-5-amine
1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
